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Note for: Clinically Relevant Concentrations of Anticancer Drugs: A Guide for Nonclinical Studies Doi: 10.1158/1078-0432.CCR-16-3083 Aim of this paper; Giving a guideline for setting up the in vitro experiment on cell line, esp. concentrations by which it makes some sense when translated back to clinical level. Extraction; For doing experiment with FDA-approved drug – it is better to search for pharmacokinetics as well as toxicity of particular drug. Thus, we can design the experiment which will be more clinically relevant.  Guiding dose and concentration selection – providing comprehensive compilation of human plasma exposures for drug-approved by the FDA for used in oncology. Sources of FDA-approved drug NCI – cross-checked with MediLexicon and Centerwatch Pharmacokinetic search through databases – original literature or conference abstract Using Cmax (maximum plasma concentration) and the integrated area under the plasma concentration–time curve (AUC) associated with the highest...