Research Interests
Current research:
Our current research group is focusing on the DNA repair pathways, especially, DNA double-strand break repairs. DNA repair is a vital mechanism and its malfunction can cause cancer. In contrast, the cancer cells also exploit the repair mechanism to facilitate tumor growth. Since the DNA repair mechanism is complex, thus, there are numbers of genes/proteins which their precise role in carcinogenesis is elusive. To explore the function of novel DNA double-strand break repair genes/proteins in carcinogenesis, our research group have used the reverse genetic approach to understand the mechanism. Because the targeted-therapy in the DNA repair pathway is very expensive and limited, we would like to search for the new lead compounds which could be developed in our country. We are now setting up the biosensor based on DNA double-strand break repair and using the high throughput screening technology (HST) to find the candidate compounds that are from local endophytic extracts. We are also interested in the structure-function relationship of DNA repair proteins by using heterologous expression to produce and create 3D structure from the candidate proteins. Besides, we would like to use the computational approach for drug design, specifically from the endophyte that has been screened through HST.
Research keywords: DNA repair, Endophyte, High-throughput screening, Heterologous Expression
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