Note: Cancer TARGETases: DSB repair as a pharmacological target
Note: Cancer TARGETases: DSB repair as a pharmacological target (doi: 10.1016/j.pharmthera.2016.02.007) DNA is not just the plain sequences which contain ATCG but we have to consider how it form the secondary structure within the strand, how it folds with the histone --> these are related to replication as well as DNA repair process. Some studies show that heterochromatin (tight) and euchromatin (loose) has been repaired by different repair mechanisms. DNA repair, esp. DSB is good targets since it can sensitize the cancer cell to the conventional treatment. 1. over-expression 2. synthetic lethality partner (which relied on DSB repair) This paper wants to review the suggested "targets" for the enzymes (ending with "ases") in the DSB pw. "TARGETase" 1. Kinases (adding the phosphate group) 2. Phosphatase (removing the phosphate group) 3. Nucleases (cutting the DNA strand at the phospho diester bond) 4. Helicase (unwinding the ...