Note: Gene-environment interactions within a precision environmental health framework
Note: Gene-environment interactions within a precision environmental health framework https://doi.org/10.1016/j.xgen.2024.100591 Disease etiology complex gene+environment interaction (GEI) measuring environmental factors advantage of GEI analysis evolution of GEI study Gene-environment to genome-wide interaction (GWI) Multi-omics Advancement in GEI analysis methods Large scale datasets Translation of GEI finding -- > precision environmental health (PEH) Significance if GEI for disease prediction and prevention Advocate for integrating exposome into PEH omics studies โดยปกติแล้วมีการประมาณการว่าโรคที่เกิดขึ้นมาจาก สวล สัก 50-80% PEH genetic + epigenetic + environment + system-level data Identifying environmental causes Identify biomarkers of exposure Develop new prevention and intervention strategies Precise risk assessment Personal information -- genetic susceptibility Environmental exposure Gene-environment interactions Linear modeling frameworks are statistical approach...