Note for: Potential Strategies to Target Protein-Protein Interactions in the DNA Damage Response and Repair (DDR) Pathways
Note for: Potential Strategies to Target Protein-Protein Interactions in the DNA Damage Response and Repair (DDR) Pathways doi: 10.1021/acs.jmedchem.7b00358 This paper focus on protein-protein interaction of protein in DNA damage response and repair pathways. 1. How to select the target PPI site base on its function 2. Functional rational and biochemical feasibility to identify a PPI inhibitor 26 PPI discuss in this paper – include BER, MMR, NER, NHEJ, HR, TLS and ICL Why focusing on PPI in DDR - Targeting protein in DDR is not easy --> many DDR proteins are unconventional drug targets (example of conventional drug target – cell surface -- G-protein coupled receptor, ion-channel or conventional enzyme – protease/kinase) - Drawback for DDR – assay is difficult for screening - ...