My note on paper: Molecular diagnosis of colorectal tumors by expression profiles of 50 genes expressed differentially in adenomas and carcinomas
Paper: Molecular diagnosis of colorectal tumors by expression profiles of 50 genes expressed differentially in adenomas and carcinomas (doi: 10.1038/sj.onc.1205518) Abstract: Most colon cancer develop from: -adenoma (benign tumor of epithelial tissue with glandular origin) to carcinoma Gap: unk molecular mechanisms of this transition Aim: -analyzing gene-expression profiles of 20 colorectal tumors using microarray 23,040 genes panel *9 adenomas (pre-malignant) *11 differentiated adenocarcinomas (malignant) Result: -identified 51 upregulate vs normal colonic epithelium -identified 376 downregulate vs normal colonic epithelium -identified 50 different between adenomas vs carcinomas ---- Intro: -Mention about the advance stage of colorectal cancer which therapeutic is not effective -Seek for early stage detection of colorectal cancer or pre-malignant lesion - block before further advance development Results: 1. 771 genes passed the determined criteria 2...