Note for: Molecular Role of RNF43 in Canonical and Noncanonical Wnt Signaling
Note for: Molecular Role of RNF43 in Canonical and Noncanonical Wnt Signaling (doi: 10.1128/MCB.00159-15) It is a bit hard to follow when reading this paper. Wnt1 class-- canonical Wnt go through beta-catenin Degradation complex includes; 1.adenomatous polyposis coli (APC) 2.axin 3.casein kinase Ialpha (CKIalpha) 4.glycogen synthase kinase 3beta (GSK-3beta) No Wnt-stimulant --> beta catenin is phosphorylated by degradation cpx leading to degradation by ubiquitin proteasome system by interact through SCFbetaTrCP ubiquitin ligase Finalized Wnt-catenin activation --> produce c-Myc which maintains undifferentiated state of cells. Wnt5a class-- non-canonical Wnt 1.not cause accumulation of beta-catenin and no induction of target genes 2.involve in cell polarity and cell migration+antagonizes Wnt/beta-catenin -- play role as tumor suppressor RNF43 suppresses both canonical and non-canonical but in different manner -- The research quest...