Note for RNF138
Two papers that I have read; one is the short communication which briefs the major finding of RNF138 contributing to DNA repair. The other paper is the original paper which performed the experiments to show that RNF138 is the new finding regulator of HR. Note for – 1. RNF138 joins the HR team (doi: 10.1038/ncb3262) 2. The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice (doi: 10.1038/ncb3259) RNF138 will be a good target for the choice switching between HR and NHEJ. Protein modification by ubiquitin has a central role in regulating DSB repair. Each cell cycle fate, will be controlled by different sets of protein through the ubiquitination process, like in this case, it is showed that RNF138 promote Ku ubiquitination during S and G2 phase when resection is operational. Cell cycle stage and DNA end resection are believed to regulate the commitment to HR repair. This study identifies RNF138 (Ub-E...