Random Records

Paper: Reversing effect of ring finger protein 43 inhibition on malignant phenotypes of human hepatocellular carcinoma (doi: 10.1158/1535-7163.MCT-12-0672) Abstract: Gap- role of RNF43 in hepatocellular carcinoma is unk RNF43 is overexpressed in HCC and correlate *vascular invasion *poor tumor differentiation *advanced tumor stage Functional study (knock down): *induce apoptosis *inhibit proliferation *inhibit invasion *inhibit proliferation *inhibit colony formation *inhibit xerograft growth Microarray results: *229 genes different between KD and Vector *analysis of 229 genes involves many cellular process: -- cell proliferation -- cell adhesion -- cell motility -- cell death -- DNA repair -- etc. Suggested therapy: since RNF43 is related to tumorigenesis, it could be the drug target to treat HCC ---- Gap: there is the study of RNF43 on the colorectal cancer but not HCC ---- Finding: 1. RNF43 is highly expressed in the HCC and related to p...

15 September 2015 (last day!) Attend only one session HCC Early Diagnostic and Screening (Dr.Taya) Top ten tips Survival is poor Thailand is the number one in Asian pacific region Survival is very low since patients always comes when chronic How to improve - using the bclc staging system which has the criteria to treat in each step (it is basically in Spain Step by step to make it better Prevention Early diagnostic Treatment Palliation Symptoms occur late, detection late cause patients to have low survival rate  90.2% does not get the targeted-therapy Early diagnostic; screening increases the early stage of the detections and improve survival rate Problem on the screening like ultrasound (some ppl cannot afford), doctors might miss recognition the risk of hbv, sound like it still has a problem on the screening Surgery and Liver Transplantation (Dr.Prawat) Next for the treatment (surgery and transplantation) Su...