My note on paper: The crosstalk between Wnt/beta-catenin signaling pathway with DNA damage response and oxidative stress: Implications in cancer therapy
Paper: The crosstalk between Wnt/beta-catenin signaling pathway with DNA damage response and oxidative stress: Implications in cancer therapy (doi:10.1016/j.dnarep.2017.01.003) Before that we thought wnt signaling might not be related to DNA repair pathway, at all. Then we find this paper writing the review of wnt signaling contributing to DNA damage response and a bit of DNA repair. wnt signaling: 1. control gene expression 2 cell polarity 3. cell adhesion 4. cell behavior 5. DNA damage response --- Oxidative stress affect the wnt signaling, oxidative stress can cause the DNA lesion --- scope of this paper; review on the crosstalk of DDR, DNA repair, cellular activities through the wnt signaling pw. DDR: 1. sense the damage 2. transduce the signal to effector 3. determine the cell fate; cell cycle, fix, or death wnt signaling 1. determine the cell fate 1.1 cell proliferation 1.2 apoptosis 2. induce DDR through various protein 2.1 H2Ax 2.2 p16-INK4...