Note for: Effects of double-strand break repair proteins on vertebrate telomere structure
Note for: Effects of double-strand break repair proteins on vertebrate telomere structure (Nucleic Acids Res. 2002 Jul 1; 30(13): 2862–2870) Phenotype between mouse and DT40 on the telomere --> Ku(-/-) different At the very end; the authors conclude that "significant species-specific differences" in telomeric fn of DSB repair proteins. Telomeres are stable structure and invisible to DNA repair machinery, or else there will be the fusion of chromosome. Telomeres --> appeared as DNA-protein cpx. --> selective for telomerase to access but not end-DNA processing enzymes. There is the report showing that if there is no telomerase, telomere is maintained by recombination-based pw. Evidents showed that when KO genes in DNA repair group --> there is the defects in telomere structure; 1. telomere shortening 2. alterations to terminal DNA structure 3. end-to-end fusions Gap; They don't know how DNA repair protein involved with the ...