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Note: Proteomic and Glycosylation Analysis of Biotherapeutic Proteins Webinar hosted by : Bioprocess Research and Innovation Centre (BRIC) Application of mass spectrometry to Biopharma https://www.ema.europa.eu/en https://www.ema.europa.eu/en/human-regulatory/research-development/scientific-guidelines/biologicals/biologicals-active-substance#manufacture,-characterisation-and-control-of-the-active-substance-section ตัวอย่างที่เขายกมาคือ monoclonal antibody ก็คือ ต้องโชว์ว่าโคลนตัวนี้สามารถที่จะผลิต protein ที่เหมือนกับ genetic materials หรือเปล่า และแต่ละลอตมีปัญหาหรือเปล่า สิ่งที่เราอ่านก็คือ peptide map แล้วเอามาเทียบกันในแต่ละลอต IgG – glycosylated protein – glycan on the protein must be characterized, depending on the cell types you are using – glycosylation pattern is very different in each cell type. Heterogeneity มี micro and macro Micro ต่างกันที่ side chain นิดเดียว Macro ต่างกันที่ pattern ที่ไป glycosylate เลย ขึ้นอยู่กับว่าเราจะดีเทคแบบไหน วิธีดีเทคแต่ละแบบก็จะ consume เวลา ...

Note from  Annual Meeting of the Thai Society for Biotechnology and International Conference (TSB 2018) I enjoy the tissue engineering part at the most. Tissue engineering preparation 1. facing the issue production inconsistency - vary lot by lot 2. try to use robot arm to solve the issue, however, there are some steps which the robot arm could not replace the human labor. The robot arm in some extent is much slower and less delicate in term of movement than human labor. 3. learning that Thailand so far could not produce the robot arm + clean room platform - KMUTT (Bio-processing unit - pilot plant) makes the collaboration with Japan -> to make this comes to reality -- though Thai side could not produce the robot arm, at least, the team can make the software to control the arm as well as to design the workflow. 4. There are many things that all the physicians mentioned, especially when applying to the patients; - iPS technology was awarded by the Nobel prize in the year...