Note for: Impact of DNA repair pathways on the cytotoxicity of piperlongumine in chicken DT40 cell-lines
Note for: Impact of DNA repair pathways on the cytotoxicity of piperlongumine in chicken DT40 cell-lines (doi: 10.18632/genesandcancer.26) One of the paper which was cited by this one, has just been retracted recently (2018, Sep -- Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature. 2011;475:231-4 ). It was the original work which showed that Piperlongumine can generate ROS which eventually was the major mechanism killing the cancer cell lines. Piperlongumine induces ROS. Aim; examine the contribution of ROS-induced DNA damage to the cytotoxicity by piperlongumine. Method; various DNA repair-deficient chicken DT40 cell-lines with a single DNA repair gene deletion were tested for cellular sensitivity to piperlongumine. ROS is necessary for several physiological responses, including differentiation, immunity, metabolic adaptation and autophagy. A fine balance between the production of ROS and the detoxifi...