I have heard these two trails for the first time at JCMS2017 from Dr. Somponart (SISP). Besides, I have heard my colleague talked about her principal investigator want to examine whether cholangiocarcinoma has the mutations that are drugable to the current drug market, especially in Thailand, where not many choices of the affordable targeted therapy are available. I think it is quite useful, at least, for me to have a very short note on it. Article: Novel Precision Medicine Trial Designs Umbrellas and Baskets Ref: 10.1001/jamaoncol.2016.5299 Precision concept: Finding the specific mutations and get the precise drug to treat -- Before the precision medicine era: *one size fits all -- specific mutation driving cancer Trend is changing since new technology + minor population want to be completely free from cancer *initiate two new differential trail designs *Umbrella trial - focus on one type of cancers but different genetic mutations (based on its origina...
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