Note for: Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention doi: 10.1126/science.aaf9011 This paper reveals a mutation in cancers, mostly occur from error in replication (2/3) -- theory observes the replication of normal stem cell divisions and relates to cancer incidence in a different country. Cancer comes from gradual accumulation of driver gene mutations which results from increased cell proliferation. Factors that contribute to mutation Environment (E) Hereditary (H) -- identify through the genes responsible for cancer predisposition syndrome Random (R) mistake during normal DNA replication -- thus cancer arises more in some tissues Three mutations occur every time a normal stem cell divides. Their observation -- number of endogenous mutations ® results from stem cell divisions in a tissue. Determine 69 countries with a variety of environments throughout the world -- representing 4.8 billion people (2/3 world population). Using 423 cancer registr...
