Note: The DNA damage response and cancer therapy
Note: The DNA damage response and cancer therapy_2012 Doi: 10.1038/nature10760 Future issues; Pharmacological targeting Biochemical and genetic interactions between the various DNA repair pws -- not clearly understood Having small potent inhibitors which specifically inhibits particular pw facilitating the interplay between DNA repair pws. Cancer stem cells and tumor micro-environment Systemic knowledge in DNA damage and DDR in stem cells need to be explored Genomic scar Cancer being classified according to their underlying pattern of pathogenic mutations Sequence scare -- reflects bot mutagens which tumor has been exposed to and repair processes that have to operated to mitigate their impact Example; HRD Microsatellite instability Mismatch repair is defective Matching molecular signatures of DNA mutation and repair -- require functional biomarkers -- which identify DDR defect and facilitate in the selection of therapy Example -- RAD51 foci formation Requiring genotoxic stress fol...