Note for: Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
Note for: Roles of eukaryotic topoisomerases in transcription, replication and genomic stability (doi: 10.1038/nrm.2016.111) Their catalytic intermediates, the topoisomerase cleavage complexes (TOPcc), are therapeutic targets of various anticancer drugs. E ngage specific repair pathways, such as those mediated by tyrosyl-DNA phosphodiesterase 1 (TDP1) and TDP2 and by endonucleases (MRE11, XPF–ERCC1 and MUS81). Aim of this paper; 1.review roles of Topo in mediating chromatin dynamics, transcription, replication, DNA damage repair and genome stability. 2.dysregulation of topoisomerase -- neurodegenerative disease, immune disorder and cancer DNA topoisomerase; 1.solve DNA topological problems 2.occur during replication and transcription Important in both nuclear and mitochondrial genomes. Each isoform of topoisomerase has shared and specialized roles. Top2a and Top2b -- relax negatively supercoiled DNA Top2a requires for chromosome segregation (dividing...