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Showing posts from October, 2017

Useful links (updated: 2024-04-22)

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Tracking the parcel 1.Logistics tracking https://t-lerksuthirat.blogspot.com/2020/06/logistics-links-tracking-parcel.html ----------------- For Ramathibodi Hospital staff 1.Mini Core Facilities https://minicore-rarc.blogspot.com/ Sharing the passion for the instruments that I use frequently. 2. Research fund and data analysis https://www.rama.mahidol.ac.th/research/fundsandanalysis/ 3. Online reserve meeting room Research Center RAMA http://10.6.155.100/rai/ 4.MU Legal Office https://op.mahidol.ac.th/la/ 5.Safety training/self-educate @ Research Center RAMA https://sites.google.com/site/rclabsafety/ 6. RC-related forms and document (via LAN) \\10.6.155.100\f\ แบบฟอร์มต่างๆสำนักงานวิจัย http://wss9/sites/hospital/research  (through RAMA only intranet) 7.Personal performance agreement evaluation https://intra9.rama.mahidol.ac.th/hc/th/e-pa https://www3.ra.mahidol.ac.th/ePerformance/ 8.Research Division -Mahidol University https://op.mahidol.ac.th/ra/ 9.ACMR-Academic

My note on paper: Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer

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Paper: Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer (doi:10.1073/pnas.0604206103) Abstract: Chromosomal instability (CIN+) 1. hallmark of most colon tumors 2. promote tumor progression by increasing rate of genetic aberration 3. occur from mitosis/spindle checkpoint defect Gap: Molecular mechanism is unk Rational: 1. colon cancer develop majorly from mutation of APC (Anaphase-promoting complex) 2. malfunction of APC causes wnt/b-catenin activation --> activate conductin/AXIN2 Research results: 1.wnt/catenin activation causes CIN via up-regulation of conductin 2.human colon cancer with CIN - found conductin higher 3.conductin is higher during the mitosis 4.conductin is localized with mitotic spindle of colon cancer cells 5.conductin binds polo-like kinase 1 6.when APC is forcibly downreglated by iRNA - conductin is ectopic upregulated lead to CIN in chromosomal stable colon cancer 7.higher expression of conductin disrup

Neuroplasticity - what the brain can be changed and reconnected to the things surrounding.

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I really love this video, I have been interested in neuroplasticity for a while ago, I have been interested this term "neuroplasticity" while I was attending the SCPA501 course at the Department of Pathology. In the course, one of the group was assigned to present the Psychoneuroimmunology which is part of the immunological disorder. While I was searching for the Psychoneuroimmunology, neuroplasticity had come across. Dr. Lara Boyd from the University of British Columbia has given a wonderful TedTalk on the brain research. There are three key factors she mentioned in the talk that affect the neuroplasticity and of course the learning ability. 1. Chemical -- brain cells communicate each other by sending the signal to what we call as "neurotransmitter". It h appens very rapidly and it facilitates the short-term memory and motor skill (the ability to control the muscle). 2. Structural changes -- how brain cells rearrange as the network,  to support the communic