Random Records

Tracking the parcel 1.Logistics tracking https://t-lerksuthirat.blogspot.com/2020/06/logistics-links-tracking-parcel.html ----------------- For Ramathibodi Hospital staff 1.Mini Core Facilities https://minicore-rarc.blogspot.com/ Sharing the passion for the instruments that I use frequently. 2. Research fund and data analysis https://www.rama.mahidol.ac.th/research/fundsandanalysis/ 3. Online reserve meeting room Research Center RAMA http://10.6.155.94/RAI/index.php/roombooking/index/1 4.MU Legal Office https://op.mahidol.ac.th/la/ 5.Safety training/self-educate @ Research Center RAMA https://sites.google.com/site/rclabsafety/ 6. RC-related forms and document (via LAN) http://wss9/sites/hospital/research/DocLib/Forms/AllItems.aspx (through RAMA only intranet) 7.Personal performance agreement evaluation https://intra9.rama.mahidol.ac.th/hc/th/e-pa https://www3.ra.mahidol.ac.th/ePerformance/ https://pms.mahidol.ac.th/  (new) 8.Research Division -Mahidol Univer...

Paper: Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer (doi:10.1073/pnas.0604206103) Abstract: Chromosomal instability (CIN+) 1. hallmark of most colon tumors 2. promote tumor progression by increasing rate of genetic aberration 3. occur from mitosis/spindle checkpoint defect Gap: Molecular mechanism is unk Rational: 1. colon cancer develop majorly from mutation of APC (Anaphase-promoting complex) 2. malfunction of APC causes wnt/b-catenin activation --> activate conductin/AXIN2 Research results: 1.wnt/catenin activation causes CIN via up-regulation of conductin 2.human colon cancer with CIN - found conductin higher 3.conductin is higher during the mitosis 4.conductin is localized with mitotic spindle of colon cancer cells 5.conductin binds polo-like kinase 1 6.when APC is forcibly downreglated by iRNA - conductin is ectopic upregulated lead to CIN in chromosomal stable colon cancer 7.higher expression of conductin di...