My note on paper: Analysis of somatic microsatellite indels identifies driver events in human tumors
Paper: Analysis of somatic microsatellite indels identifies driver events in human tumors (doi: 10.1038/nbt.3966) Again, I only note for the gene that I have been interested. Microsatellites; *variable-lengths repeats of short DNA motif (usually 1-6 repeat) *exhibit of high rate of mutation, esp, indel Gap: *the relationship of somatic MS indels to cancer is unk, bc of the technical limitation What they do: Present two tools MSMUTect - accurate detection of somatic MS indels MSMutSig - identification of genes containing MS indels Apply the tool to whole-exome from -6747 human tumors; 20 tumors -identified new >1000 MS indels in cancer genes -be able to distinguish microsatellite -stable from microstellite instability -identified 7 MS indel hotspots: *ACVR2A, RNF43,JAK1,MSH3 (previously known cancer genes -- meaning support the tumor growth) *ESRP1,PRDM2 and DOCK3 --- MS; *repetitive short sequences (1-6 bp) *abundant in non-transcribed regio...