My note on paper: RNF43 mutations are recurrent in Chinese patients with mucinous ovarian carcinoma but absent in other subtypes of ovarian cancer
Paper: RNF43 mutations are recurrent in Chinese patients with mucinous ovarian carcinoma but absent in other subtypes of ovarian cancer (doi: 10.1016/j.gene.2013.08.054) Abstract: Fact- *Large scale sequencing identified prevalent RNF43 mutation in pancreatic and ovarian mucinous carcinomas *Exome sequences on RNF43 in 251 Chinese patients with distinct ovarian subtypes *2/15 (13.3%) novel heterozygous nonsynonymous mutation found in mucinous ovarian carcinoma *the mutations is highly conserved *No RNF43-mutated samples contain hotspot mutation in --DICER1 (dicer 1, ribonuclease type III), --PPP2R1A (protein phosphatase 2, regulatory subunit A, alpha), --TRRAP (transformation/transcription domain-associated protein) -- DNMT3A (DNA (cytosine-5-)-methyltransferase 3 alpha) *lack of RNF43 mutation in other subtypes suggest no functional role in that subtype Intro: Ovarian CA (OVCA) - *heterogeneity malignant *90% of OVCA are epithelial origin *10% of OV...