Quick note for Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma
Paper: Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma doi: 10.1073/pnas.1307218110. Epub 2013 Jul 11 I like the picture that the team showed the cytotoxicity assay toward PDAC cell lines by using Wnt secretion inhibitor; LGK974. LGK974 inhibits the wnt-secretion by inhibiting the enzyme called "porcupine" which add the palmitoleic acid to the wnt as an indispensable signal for its secretion. What I have learned in this publication is molecular subtyping is a very important procedure for the cancer treatment since each molecular subtype will differently response to the treatment. The main idea for this paper is that; 1. PDAC cell lines have a different molecular genotypic signature. 2. There is more than 1 factor that supporting the growth of PDAC cell lines. 3. The growth of RNF43 malfunctioned PDAC cell lines relies on the Wnt pathway (by understanding this characteristic, we can apply the wnt inhibitor to this patient...