Note for: A Proposal Regarding Reporting of In Vitro Testing Results
Note for: A Proposal Regarding Reporting of In Vitro Testing Results Doi: 10.1158/1078-0432.CCR-13-0043 Failure to translate to clinical research examples; Sorafenib Vorinostat Metformin They ask reviewer to limit the publications which reported the concentrations were not related to clinical level, to prevent the failure rate at the clinical levels. The key point for the successfulness in term of translation from in vitro to clinical – Testing with multiple cell lines Giving wide variation of sensitivity Only small portion of cell will be extremely sensitive at very low concentration This subgroup has special molecular feature which is targetable for particular drug Suggestion Cells – heterogeneity Test with many different types of cells Picking up the cell with show sensitivity with very low drug concentration Finding feature at the molecular level and tracing back to clinical level How to get rid of bad data Author proposed “desk reject” the MS which the concentrations are not ...