Thailand Lab 2017: Challenges in Natural Product and Drug Discovery
Challenges in Natural Product and Drug Discovery ---- Dr. Kappei - Eisai company, Japan Attractiveness of the resource 26% of fda approve is derived from the natural products The drugs that received from the np (natural product) - require more chemical rxn synthesis. This company can find the resource for making the drug synthesis through the collaboration, he mentioned the Asia is under explored and he would like to look for the opportunity. It sounds to me that this company has good resource in the chemoinformatics regard to the natural products. Halichondrin b to erinbulin example of success, The halichondrin is extracted from the marine organism but the resource is very limited, therefore requiring more of chemical synthesis to help. This another example of the process for the drug discovery, Pladienolide B to E70107 - The original compound requires more modification in order to make it more stable and more solubilit...