Note: In silico models for designing and discovering novel anticancer peptides

Note: In silico models for designing and discovering novel anticancer peptides

Doi: 10.1038/srep02984

Dataset: 

225 experimentally validated anticancer peptide (ACP)

• APD, http://aps.unmc.edu/AP/main.php -- antimicrobial peptides (AMP)

• CAMP, http://www.bicnirrh.res.in/antimicrobial (CAMP)

• DADP, http://split4.pmfst.hr/dadp/ (anuran defense peptides)

Majority are AMP + BROAD spectrum of anticancer activities -- > positive samples

The information on non-anticancer peptide -- > few in the literature thus they got 2,250 random peptides as non-ACP from the SWISS-PROT.

This study NEGATIVE > POSITIVE -- > imbalance dataset

Negative dataset  (2250) -- > no experimental validate!!!

Alternate dataset -- > 225 experimental validate ACP +1372 non-ACP (AMPs without ACP activities)

Available database: http://crdd.osdd.net/raghava/anticp/