Cell penetrating peptide - playing around with the metabolic different between cancer and normal cells
LONZA is the company selling the Amaxza’s reagents.
Generating peptides ( which turn into alpha-helix when exposed to acidic microenvironments like cancers.
The team used peptide as a drug carrier to specifically target the cancer cell, especially the solid tumors.
Roughly estimate the MW - > 4000 g/mol -- it seems like their peptides incorporate into the membrane but don't interfere with cell permeability otherwise it could cause inflammation (due to the internal content leakage)
Ref: https://www.cybrexa.com/wp-content/uploads/2018/12/Cybrexa-Poster-63.pdf
Patent: https://patents.google.com/patent/US20190209580A1/en?oq=US+20190209580+A1
Company profile: https://www.cybrexa.com/about/
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