Note for: The therapeutic significance of mutational signatures from DNA repair deficiency in cancer

Note for: The therapeutic significance of mutational signatures from DNA repair deficiency in cancer doi: 10.1038/s41467-018-05228-y Computational analysis on PAN cancer has revealed mutational patterns which could identify cancer types. Development of DNA repair deficiency biomarkers -- critical to determine therapeutic choice to treat repair-deficient tumours -- those therapeutic choices could be damaging agents/immunotherapy for personalized medicine In the post genomics era which sequencing tech is cheap -- there have been huge amounts of study of the sequencing of genetic instability and DNa repair deficiency in cancer. Phenotypic changes of defective DNA repair pathway can be detected through the sequencing data. Study of mutational pattern changes and copy number changes can be used to portray mutational contribution to genomic instability. 2/3 of mutation in cancers occur from error in replication Passenger mutations Not relate to oncogenesis Driver mutations Drive oncogenesis ...