Note: Big Data Management for Genomics Thailand (SI - Strategic Resesearch Forum)
Talk by Dr. Sissades Tongsima (National Biobank of Thailand) Understanding risk – > can aid us in making important life decisions to have a good health Thai-mutation database Biobank – MoPH Sequencing facility – ThaiOmics – private company run through BGI Computational infrastructure from NSTDA Operational plan Recruit patients Draw Blood sent to MoPH – extract DNA with standard protocol DNA shift to ThaiOmics (Burapa U.) Send the data to NSTDA – creating tool for users easy to use สิ่งที่เขาเอามาคือ Variation by comparing with GRCh38 Looking at frequency of each variation See further whether it effects the exons, and protein structures As of now (2023-07-17) ~30,000 have been recruited Software Variant @nnotation and prioritization ปกติแล้วจะต้องซื้อเขาเอา – หลัก ๆ คือ เอา variants ที่น่าจะมีความเกี่ยวข้องกับโรค เอาออกมา – โดยดูในเรื่องของ sequence alignment, see whether they are conserved – this step requires expert domain to interpret and feedback the platform Cancer Targeted se