LS2; flash note from the conference - Life Science in Switzerland (annual meeting)
There are three main sections in this conference;
1.Invited speakers (from both academic and industrial)
2.Oral presentation from postdocs (competition event)
3.Poster presentation (students and postdoc, mainly)
4.Career advice session (panel includes speakers with the different career path; tenure-track, entrepreneur, core facility, editorial role and career advice in life science).
Below is the list of interesting talk during the conferences
Invited speakers (academic),
Proteomics in 3D: Dr.Paola Picotti (ETH, Zurich)
She has a chemistry background and later on has moved her research to study Alzheimer disease. She used her knowledge from the chemistry background by using proteomics approaches to study the aggregation of α-synuclein. Her lab is playing around with the temperature-induced structural changes in the protein. Thus, the patterns of MS will be different due to the accessibility of trypsin to digest the aggregation of α-synuclein. The MS profile is compared with the other techniques to confirm the structural changes during the time-course. Therefore, it requires the expert with different filed of expertise to analyze the data. Her team’s work regarding these techniques have been published in Nature Biotechnology as well as Nature protocol. Publication to follow -- PMID: 31841731, 29072706, 25218519, 29072706
Phosphate sensor, SPX: Dr.Rebekka Wild (University of Grenoble, France)
She has solved the SPX domain’s structure which previously was reported as unknown-function protein. She has uncovered the function of this protein using the X-ray crystallography. This domain regulates the phosphate homeostasis which could be found in both animal and plant. Phosphate is an important element for the living organisms, for example, plant growth and energy level within the cells. This is the ground-breaking work since it reveals the molecular mechanism of how phosphate level regulates the cell’s function. Her work was published in Science journal. Publication to follow -- PMID: 27080106
Tracking cellular ancestor: Dr.Alex Schier (University of Basel)
He is basically using the single-cell analysis approach (based on RNA-seq) to create the cellular hierarchy. He used Zebra fish as the model to study as such. He started to collect the cells from the beginning of fertilization until the embryo was developed. This requires a massive amount on the data analysis to track which cells originate from which developmental layer. By using this approach, his team is able to identify the key cellular events supporting the embryogenesis, for instance, unfolded protein response and DNA damage response. His amazing work was published in Science journal. Publication to follow -- PMID: 29608178
Spindle assembly process in mammalian eggs: Dr.Melina Schuh (Max-Planck Institute for biophysical chemistry, Germany)
I have learned that mammalian female oocytes don’t have classical centrosome, thus they are prone to chromosomal aberration during the meiosis. She showed the live-cell image of oocyte meiotic cell division and demonstrated that there was a transient multipolar formation during the process. Thus, it is likely to have the defect if the proteins involving in the process are defective. Since the oocyte is very hard to do genome editing to study the effect of a particular gene on the meiosis division. Her team has used another cutting-the-edge technique, so-called “trim-away” which can specifically degrade “endogenous” protein within the cells (PMID: 30250286). As a result, her team can study the effect of proteins related to chromosomal segregation. Her work was published in Science journal. Publication to follow -- PMID: 31249032
How stress induced grey hair: Dr.Ya-Chieh Hsu (Harvard University, USA)
Her work has gone viral as the current stage due to it is closely related to daily life. She has collaborated with the lab which has a good mouse model to answer the question on the mechanism underlying stress-induced grey hair. There are three factors that her team thought of; 1. immune-mediated, 2. hormone from adrenal grand mediated and 3. sympathetic induced – all of these factors have been elaborated through the mouse study. The result showed that it was because of sympathetic nerve gets activated when stress was induced. Norepinephrine was released and causing the melanocyte stem cell rapidly divided and exhausted eventually. As a result, the melanocyte could not produce the pigment which makes the hair dark. Her work was published in Nature journal. Publication to follow -- PMID: 31969699
Invited speakers (industrial), Food peptidomics: Micheal Affolter (Nestle Research, Lausanne)
He basically focuses on the peptides as part of the food ingredients, especially formulated milk. There are pros and cons regarding peptides science in food; Pros – part of the micronutrients, food texture and taster, source of amino acids and bioactive peptide Con – allergen, toxin and antinutritional factor The research team has investigated proteomics and peptidomics profiles of human breast milk. By using the information from human breast milk, his team dissects which peptides are bioactive and might benefit for the customers, therefore, the company can formulate the milk from a cow and precisely make diverse types of milk products that are specific for each condition, for example, hyper-allergenic group or indigestion condition.
PI of tomorrow session: professional research pitch by the outstanding postdoc
Dr.Eleonora Porcu: using the statistic tool to precisely predict the phenotype based on GWAS data. Her work was published in Nature communication. (PMID: 31341166)
Dr.Thomas Auer: he investigated the linkage between environment and behavior of the fruit fly through the olfactory genetic analysis. He tried to generate the connectome which linking the information from the smell through the olfactory receptor (which has been determined by the genetic trait) and the outcome behavior. This work was published in bioRxiv as the pre-print to let the readers give feedback. (doi: 10.1101/546507)
Dr.Olga Murina: she is interested in endogenous DNA damage response. She used the gene-editing (CRISPR-Cas9) approach to study the synthetic lethal to PARPi. Later, RNASEH2B was found out to be the synthetic partner of PAPR. This work was published in Nature. (PMID: 29973717)
Dr.Joachim Moser von Filseck: he investigated how ESCRT-III polymers affect the geometry of lipid bilayers. His work used Cryo-EM to investigate the membrane deformation. This work was published in bioRxiv as the pre-print to let the readers give feedback. (doi: 10.1101/716308)
Panel discussion (career path);
• The university should have the career advice team since being in tenure-track route will success only 1%, currently – the tenure-track is very competitive. There is another alternative career which postgrad can apply for.
• Considering hard on the life-style and picking the appropriate job that fits with the routine life.
• To do a postdoc, remember to choose the PI which provides the environment supporting the future career path as well as being able to publish in a good profile journal.
Ref: https://annual-meeting.ls2.ch/
1.Invited speakers (from both academic and industrial)
2.Oral presentation from postdocs (competition event)
3.Poster presentation (students and postdoc, mainly)
4.Career advice session (panel includes speakers with the different career path; tenure-track, entrepreneur, core facility, editorial role and career advice in life science).
Below is the list of interesting talk during the conferences
Invited speakers (academic),
Proteomics in 3D: Dr.Paola Picotti (ETH, Zurich)
She has a chemistry background and later on has moved her research to study Alzheimer disease. She used her knowledge from the chemistry background by using proteomics approaches to study the aggregation of α-synuclein. Her lab is playing around with the temperature-induced structural changes in the protein. Thus, the patterns of MS will be different due to the accessibility of trypsin to digest the aggregation of α-synuclein. The MS profile is compared with the other techniques to confirm the structural changes during the time-course. Therefore, it requires the expert with different filed of expertise to analyze the data. Her team’s work regarding these techniques have been published in Nature Biotechnology as well as Nature protocol. Publication to follow -- PMID: 31841731, 29072706, 25218519, 29072706
Phosphate sensor, SPX: Dr.Rebekka Wild (University of Grenoble, France)
She has solved the SPX domain’s structure which previously was reported as unknown-function protein. She has uncovered the function of this protein using the X-ray crystallography. This domain regulates the phosphate homeostasis which could be found in both animal and plant. Phosphate is an important element for the living organisms, for example, plant growth and energy level within the cells. This is the ground-breaking work since it reveals the molecular mechanism of how phosphate level regulates the cell’s function. Her work was published in Science journal. Publication to follow -- PMID: 27080106
Tracking cellular ancestor: Dr.Alex Schier (University of Basel)
He is basically using the single-cell analysis approach (based on RNA-seq) to create the cellular hierarchy. He used Zebra fish as the model to study as such. He started to collect the cells from the beginning of fertilization until the embryo was developed. This requires a massive amount on the data analysis to track which cells originate from which developmental layer. By using this approach, his team is able to identify the key cellular events supporting the embryogenesis, for instance, unfolded protein response and DNA damage response. His amazing work was published in Science journal. Publication to follow -- PMID: 29608178
Spindle assembly process in mammalian eggs: Dr.Melina Schuh (Max-Planck Institute for biophysical chemistry, Germany)
I have learned that mammalian female oocytes don’t have classical centrosome, thus they are prone to chromosomal aberration during the meiosis. She showed the live-cell image of oocyte meiotic cell division and demonstrated that there was a transient multipolar formation during the process. Thus, it is likely to have the defect if the proteins involving in the process are defective. Since the oocyte is very hard to do genome editing to study the effect of a particular gene on the meiosis division. Her team has used another cutting-the-edge technique, so-called “trim-away” which can specifically degrade “endogenous” protein within the cells (PMID: 30250286). As a result, her team can study the effect of proteins related to chromosomal segregation. Her work was published in Science journal. Publication to follow -- PMID: 31249032
How stress induced grey hair: Dr.Ya-Chieh Hsu (Harvard University, USA)
Her work has gone viral as the current stage due to it is closely related to daily life. She has collaborated with the lab which has a good mouse model to answer the question on the mechanism underlying stress-induced grey hair. There are three factors that her team thought of; 1. immune-mediated, 2. hormone from adrenal grand mediated and 3. sympathetic induced – all of these factors have been elaborated through the mouse study. The result showed that it was because of sympathetic nerve gets activated when stress was induced. Norepinephrine was released and causing the melanocyte stem cell rapidly divided and exhausted eventually. As a result, the melanocyte could not produce the pigment which makes the hair dark. Her work was published in Nature journal. Publication to follow -- PMID: 31969699
Invited speakers (industrial), Food peptidomics: Micheal Affolter (Nestle Research, Lausanne)
He basically focuses on the peptides as part of the food ingredients, especially formulated milk. There are pros and cons regarding peptides science in food; Pros – part of the micronutrients, food texture and taster, source of amino acids and bioactive peptide Con – allergen, toxin and antinutritional factor The research team has investigated proteomics and peptidomics profiles of human breast milk. By using the information from human breast milk, his team dissects which peptides are bioactive and might benefit for the customers, therefore, the company can formulate the milk from a cow and precisely make diverse types of milk products that are specific for each condition, for example, hyper-allergenic group or indigestion condition.
PI of tomorrow session: professional research pitch by the outstanding postdoc
Dr.Eleonora Porcu: using the statistic tool to precisely predict the phenotype based on GWAS data. Her work was published in Nature communication. (PMID: 31341166)
Dr.Thomas Auer: he investigated the linkage between environment and behavior of the fruit fly through the olfactory genetic analysis. He tried to generate the connectome which linking the information from the smell through the olfactory receptor (which has been determined by the genetic trait) and the outcome behavior. This work was published in bioRxiv as the pre-print to let the readers give feedback. (doi: 10.1101/546507)
Dr.Olga Murina: she is interested in endogenous DNA damage response. She used the gene-editing (CRISPR-Cas9) approach to study the synthetic lethal to PARPi. Later, RNASEH2B was found out to be the synthetic partner of PAPR. This work was published in Nature. (PMID: 29973717)
Dr.Joachim Moser von Filseck: he investigated how ESCRT-III polymers affect the geometry of lipid bilayers. His work used Cryo-EM to investigate the membrane deformation. This work was published in bioRxiv as the pre-print to let the readers give feedback. (doi: 10.1101/716308)
Panel discussion (career path);
• The university should have the career advice team since being in tenure-track route will success only 1%, currently – the tenure-track is very competitive. There is another alternative career which postgrad can apply for.
• Considering hard on the life-style and picking the appropriate job that fits with the routine life.
• To do a postdoc, remember to choose the PI which provides the environment supporting the future career path as well as being able to publish in a good profile journal.
Ref: https://annual-meeting.ls2.ch/
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