Note from symposium: mRNA as genetic medicines: the next-generation biologics toward ATMPs and vaccines
I learn together with Gemini during the symposium, need to remind some concepts in structural mRNA and immunology - I used to work with adoptive T-cell transfer to fight against Blastomyces infection . During that time we usually used peptide (tetramer), and live-attenuated as the antigens to initiate the cellular immune response. With the successfulness of mRNA vaccine during the COVID, there is a huge development on using mRNA instead of protein/peptide/whole cells to initiate immune response. Hand-written note Gemini 2.5 Flash Prompt: What is cap 2 structure in mRNA Ans: The "Cap2" structure in mRNA refers to a specific modification found at the 5' end of messenger RNA molecules in eukaryotes. It's a more elaborate version of the basic mRNA cap. Here's a breakdown: The Basic Cap (Cap0): All eukaryotic mRNAs start with a 5' cap, which is an inverted 7-methylguanosine (m7G) linked to the first transcribed nucleotide (N1) via a 5'-5' triphosph...