Random Records

Ethics related to traditional medicine. It is very important for grant proposals, scientific integrity and patients' safety. Link relates to this topic:  https://t-lerksuthirat.blogspot.com/2021/05/note-musc-research-forum-new-normal.html

Install anaconda https://www.youtube.com/watch?v=5mDYijMfSzs Dealing with virtual environment python https://www.youtube.com/watch?v=mIB7IZFCE_k https://www.youtube.com/watch?v=rFCBiP9Gkoo ttps://www.youtube.com/watch?v=Uz4dadzu5i0 https://www.youtube.com/watch?v=Ro9l0eapoJU Python packages list https://pypi.org/ Downloading the building tool C++ https://docs.microsoft.com/en-us/answers/questions/136595/error-microsoft-visual-c-140-or-greater-is-require.html Some packages were developed from particular version of python.

Note: The DNA damage response and cancer therapy_2012 Doi: 10.1038/nature10760 Future issues; Pharmacological targeting  Biochemical and genetic interactions between the various DNA repair pws -- not clearly understood Having small potent inhibitors which specifically inhibits particular pw facilitating the interplay between DNA repair pws. Cancer stem cells and tumor micro-environment Systemic knowledge in DNA damage and DDR in stem cells need to be explored Genomic scar Cancer being classified according to their underlying pattern of pathogenic mutations Sequence scare -- reflects bot mutagens which tumor has been exposed to and repair processes that have to operated to mitigate their impact Example; HRD Microsatellite instability Mismatch repair is defective Matching molecular signatures of DNA mutation and repair -- require functional biomarkers -- which identify DDR defect and facilitate in the selection of therapy Example -- RAD51 foci formation Requiring genotoxic stress fol...

Note: Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations_2000 Doi: 10.1093/mutage/15.4.289 Theory of cancer formation Breakage and reunion theory Exchange theory Molecular theory Initial lesion -- chemical and physical-DNA damaging agents Artificially induced DSB IR Endonuclease Cellular (spontaneous) sources of DSB Can occur in any stage of cell cycle Briefly summarize the main causes of spontaneous DSB Topoisomerases Topo-I -- generates SSB Topo-II -- generate DSB Replication Prevalent source of DSB -- DNA replication Cell estimates to suffer ~ 10 DSB/cell cycle (estimate from spontaneous sister chromatid exchange) Meiosis V(D)J recombination Other recombinant process Transposable elements Fragile sites Extended micro- and minisatellite sequences -- potential source of DSB in mammalian genome At this time of writing (2000) -- the instability of this fragile site is not well-understood DSB as a results of excision repair Considering on t...

The Chi-square test is used to compare the differences between categorical data. My Note from Datacamp subscription - เหมือนกับว่าเรามีค่า observatory data มาแล้ว และมันจะคำนวนหาค่า expected data มาให้ โดยค่าที่เป็น expected data จะเป็นค่าที่ ค่า variable  This statistic that we've just formulated is called the chi-squared statistic. It captures the distance between a contingency table and the table you would expect if the variables were independent of one another. We found that the statistic for the relationship between party and natspac was one-point-three-three. If we calculate the statistic for the relationship with natarms, we get a much greater distance: eighteen-point-nine-seven. With this statistic in hand, you can return to the hypothesis test to answer the question of if either of these observed statistics: one-point-three-three or eighteen-point-nine-seven is so great as to lead you to reject the null hypothesis that these spending priorities are independent of political...