Life balance
As far as I have read through the literature on cancer and cellular signaling;
normal --> dysplasia (lesion) -->cancer
It is not surprising that why tumor has heterogeneity and it is hard to beat. DNA is very prone to be mutated all the times, either external or internal sources. The internal source, for example, is from the metabolites being produced in the cell to keep the cell alive - the most important term that we have heard of is reactive oxygen species (ROS). Most of the macromolecules are rich in electron, one of which is DNA. Therefore, the DNA can be oxidized and their sequences are inevitably changed.
I would say homeostasis is the term which anabolic system is equal to catabolic system. However, since our body has linked with the external environment, there ain't ways that the homeostasis will not be disturbed (for example, there might be the day that PM2.5 reaches to the hazardous level . Once the system has been interrupted, the cell will manage itself to go back to the homeostasis level. However, if the level of external sources is very potent, it could change to another stage of homeostasis, (like a new kinetic constant value in the chemical reaction once the environments have been changes and the reaction equilibrium is shifted accordingly).
Once the DNA sequences have been changed - it may and may not cause the diseases. Really depending on the location, some locations keep a very important command to control the cell function whereas other is nothing. If the location which controls the growth function is disrupted, the cell will divide more than usual and forming a well-defined mass (benign), the growth rate depends on the cell types as well as where it is being located in the body -- in general, it is lower than the malignant stage but higher than the normal. I would say benign is another new kinetic constant under a certain environment. In this stage, I would say that the genes which control either proliferation or cell death/senescence have been changed. If the DNA sequences have been changed until the cells lose the ability to control the growth and the cell can become cancerous. In this stage, I would say the cell has shifted to another kinetic constant and the k-value will be chaotically changed from time to time until the host is no longer exist!
--
In the era of single cell analysis - kind of wonder, cells are still uniform throughout the benign stage? my understanding, this characteristic would come from the observation from microscopic based.
Does invasiveness of the cancerous cell rely on the original cells which have been mutated; stem cell or senescence cell or ongoing differentiated cell?
normal --> dysplasia (lesion) -->cancer
It is not surprising that why tumor has heterogeneity and it is hard to beat. DNA is very prone to be mutated all the times, either external or internal sources. The internal source, for example, is from the metabolites being produced in the cell to keep the cell alive - the most important term that we have heard of is reactive oxygen species (ROS). Most of the macromolecules are rich in electron, one of which is DNA. Therefore, the DNA can be oxidized and their sequences are inevitably changed.
I would say homeostasis is the term which anabolic system is equal to catabolic system. However, since our body has linked with the external environment, there ain't ways that the homeostasis will not be disturbed (for example, there might be the day that PM2.5 reaches to the hazardous level . Once the system has been interrupted, the cell will manage itself to go back to the homeostasis level. However, if the level of external sources is very potent, it could change to another stage of homeostasis, (like a new kinetic constant value in the chemical reaction once the environments have been changes and the reaction equilibrium is shifted accordingly).
Once the DNA sequences have been changed - it may and may not cause the diseases. Really depending on the location, some locations keep a very important command to control the cell function whereas other is nothing. If the location which controls the growth function is disrupted, the cell will divide more than usual and forming a well-defined mass (benign), the growth rate depends on the cell types as well as where it is being located in the body -- in general, it is lower than the malignant stage but higher than the normal. I would say benign is another new kinetic constant under a certain environment. In this stage, I would say that the genes which control either proliferation or cell death/senescence have been changed. If the DNA sequences have been changed until the cells lose the ability to control the growth and the cell can become cancerous. In this stage, I would say the cell has shifted to another kinetic constant and the k-value will be chaotically changed from time to time until the host is no longer exist!
--
In the era of single cell analysis - kind of wonder, cells are still uniform throughout the benign stage? my understanding, this characteristic would come from the observation from microscopic based.
Does invasiveness of the cancerous cell rely on the original cells which have been mutated; stem cell or senescence cell or ongoing differentiated cell?
x
Comments
Post a Comment