Hypothesis on cancer
As far as I have heard and read;
1.Cancer stem cell
Cancer behaves like a stem cell. It can divide indefinitely and can differentiate into the other cell type.
2.Field cancerization
Cancer occurs when the normal cell has been chronically exposed to the carcinogens. Then the molecular genetics have been changed along the way until the injured cell loses control in cell division.
3.Mutator phenotype
It relies on the fact that the machinery of DNA replication has been less effective over time and causing the error in replication, which leads to DNA mutations. Besides, DNA repair also contributes to the mutator phenotype. Defective in DNA repair causes the accumulated DNA mutations. All of these factors, in turn, change the cellular division regulation and thereby leading to carcinogenesis.
What else?
1.Cancer stem cell
Cancer behaves like a stem cell. It can divide indefinitely and can differentiate into the other cell type.
2.Field cancerization
Cancer occurs when the normal cell has been chronically exposed to the carcinogens. Then the molecular genetics have been changed along the way until the injured cell loses control in cell division.
3.Mutator phenotype
It relies on the fact that the machinery of DNA replication has been less effective over time and causing the error in replication, which leads to DNA mutations. Besides, DNA repair also contributes to the mutator phenotype. Defective in DNA repair causes the accumulated DNA mutations. All of these factors, in turn, change the cellular division regulation and thereby leading to carcinogenesis.
What else?
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