PTM
My ABC to Protein post-modification in higher Eukaryote!
1.Phosphorylation
2.Ubiquitination
3.Acetylation
4.Methylation
5.SUMO
6.Glycosylation
7.S-nitrosylation
8.Lipidation
9.Proteolytic cleavage
10.PARylation
11.Neddylation
12.Malonylation
13.Propionylation
14.Crotonylation
15.Citrullination
16.Carbonylation
17.ADP ribosylation
18.Hydroxylation
19.Iodination
20.Addition of prosthetic group
21.Isopeptide bond
Anything else? -- and yes there is ......
It sounds to me those PTMs reflect the microenvironment within the cell, as a result, it regulates the cellular function and response.
The paper basically focuses on the epigenome (mostly histone and DNA). It is a very nice piece of illustration.
doi: 10.1080/17460441.2017.1295954
Exploring the epigenetic drug discovery landscape
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1.Phosphorylation
2.Ubiquitination
3.Acetylation
4.Methylation
5.SUMO
6.Glycosylation
7.S-nitrosylation
8.Lipidation
9.Proteolytic cleavage
10.PARylation
11.Neddylation
12.Malonylation
13.Propionylation
14.Crotonylation
15.Citrullination
16.Carbonylation
17.ADP ribosylation
18.Hydroxylation
19.Iodination
20.Addition of prosthetic group
21.Isopeptide bond
Anything else? -- and yes there is ......
It sounds to me those PTMs reflect the microenvironment within the cell, as a result, it regulates the cellular function and response.
The paper basically focuses on the epigenome (mostly histone and DNA). It is a very nice piece of illustration.
doi: 10.1080/17460441.2017.1295954
Exploring the epigenetic drug discovery landscape
---
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